Homepage | Journal of Neurology, Neurosurgery and Psychiatry …
2 days ago · Journal of Neurology, Neurosurgery and Psychiatry is a Plan S compliant Transformative Journal. Journal of Neurology, Neurosurgery and Psychiatry (JNNP)'s ambition is to publish the most ground-breaking and cutting-edge research from around the world. Encompassing the entire genre of neurological sciences, our focus is on the common disorders (stroke, multiple sclerosis, Parkinson's disease ...
Recurrent Guillain–Barré syndrome - Journal of Neurology ...
Guillain–Barré syndrome (GBS) is an acute polyradiculoneuropathy leading to flaccid paresis. Its annual incidence rate is 0.75 to 2 per 100 000.1 2 GBS is a heterogeneous disease in which approximately two-thirds of patients report a preceding incident, usually an infection, such as diarrhoea or an upper-respiratory-tract infection. Although GBS is …
Ischaemic stroke can follow COVID-19 vaccination but is much …
The COVID-19 pandemic has had a major impact on stroke. While there was marked drop in hospitalised stroke cases worldwide particularly during the first wave,1 2 epidemiological data have shown a real increase in stroke incidence with cases primarily occurring out of hospital and especially in care homes.3 Therefore, COVID-19 infection itself is …
Application of the 2021 EAN/PNS criteria for chronic inflammatory ...
Background The diagnostic value of new criteria of the European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) for chronic inflammatory demyelinating polyneuropathy (CIDP) is unknown. Methods We performed a retrospective study of fulfilment of EAN/PNS 2021 criteria on 120 consecutive patients with a clinical diagnosis of ‘suspected CIDP’ and objective treatment response, attending ...
Online First | Journal of Neurology, Neurosurgery & Psychiatry
6 days ago · Multiple sclerosis. Dynamics of choroid plexus volume is associated with the presence and development of fatigue in multiple sclerosis. MartinaRubin, PaoloPreziosa, MonicaMargoni, AlessandroMeani, ElisabettaPagani, GianlucaCorazzolla, LoredanaStorelli, DamianoMistri, MassimoFilippi, Maria ARocca. doi: 10.1136/jnnp-2024-334913.
Delirium and the risk of developing dementia: a cohort study of 12 …
Background Delirium is an important risk factor for subsequent dementia. However, the field lacks large studies with long-term follow-up of delirium in subjects initially free of dementia to clearly establish clinical trajectories. Methods We undertook a retrospective cohort study of all patients over the age of 65 diagnosed with an episode of delirium …
Marked laterality of olivopontocerebellar pathology in an …
Multiple system atrophy (MSA) is a sporadic adult-onset neurodegenerative disorder characterised by autonomic dysfunction, cerebellar ataxia and parkinsonism, each due to degeneration of the autonomic, olivopontocerebellar (OPC) and striatonigral (SN) systems with accumulation of α-synuclein (Syn) protein. Approximately, 35% of patients with MSA show asymmetric symptoms1; however ...
Amantadine treatment is associated with improved consciousness …
Objective This study determined the effect of amantadine treatment on consciousness in patients with non-traumatic brain injury. Methods We pooled individual patient data of five single-centre observational studies to determine the effect of amantadine treatment among patients with ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, community-acquired bacterial meningitis ...
Tofersen in adults with SOD1-ALS: phase 3 VALOR trial and open …
VALOR was a Phase 3, placebo-controlled trial to evaluate the clinical efficacy and safety of tofersen in adults with ALS and a confirmed SOD1 mutation (SOD1-ALS). Participants were randomised 2:1 to tofersen 100 mg (3 doses ~2 weeks apart, then 5 doses every 4 weeks) or placebo administered intrathecally. The primary endpoint was change from baseline to Week 28 in the ALS Functional Rating ...
Infections and the Guillain-Barré syndrome - Journal of Neurology ...
It has long been textbook knowledge that in most patients an infective illness precedes the development of the Guillain-Barré syndrome (GBS). About two thirds of patients report symptoms of an upper respiratory tract or gastrointestinal tract infection predating the disease by 1–4 weeks. Many diverse infectious agents have been incriminated as triggers of this acute polyradiculoneuropathy ...