In this review article, we will discuss TB pathogenesis, current treatment regimens, challenges to the global TB control, as well as current TB drug targets and their corresponding drug candidates.

Jan 17, 2025 · Tuberculosis (TB) is caused by a bacterium (or germ) called Mycobacterium tuberculosis. When a person breathes in TB germs, the germs can settle in the lungs and begin to grow.

TB results almost exclusively from inhalation of airborne particles (droplet nuclei) containing M. tuberculosis.

Further details about pathogenesis of latent tuberculosis infection (LTBI) and TB disease are described in Figure 1.3. Droplet nuclei containing tubercle bacilli are inhaled, enter the lungs, and …

In this review, we summarize the pathogenesis of TB infection, therapeutic targets, and corresponding modulators, including first‐line medications, current clinical trial drugs and molecules in preclinical …

Mar 12, 2025 · Most commonly, tuberculosis (TB) is transmitted via aerosol droplets generated when a person with the disease involving the lungs or airways (especially when involving the larynx) coughs, …

In this review, we summarize the pathogenesis of TB infection, therapeutic targets, and corresponding modulators, including first-line medications, current clinical trial drugs and molecules in preclinical …

Jun 30, 2025 · In this Review, we outline the physiological and metabolic features thought to underpin the survival, evasion and subversion strategies employed by M. tuberculosis as it drives a cycle of...

Jan 6, 2025 · People at risk for TB fall into two broad categories: TB bacteria are carried in airborne particles of 1–5 microns in diameter called droplet nuclei. Infectious droplet nuclei are generated …

The pathogenesis of tuberculosis involves a dynamic interaction between host and pathogen. From the time of Koch's identification of the causative agent of tuberculosis until relatively recently, …