CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and …

Expressed on the surface of CD8+ T cells, the CD8 co-receptor is a key component of the T cells that contributes to antigen recognition, immune cell maturation, and immune cell signaling.

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...

Aug 24, 2023 · Mutations in alpha chain cause CD8 deficiency, with recurrent bacterial infections (J Clin Invest 2001;108:117) Accumulate in advanced atherosclerotic plaques (Hum Pathol 2008;39:1756)

Jul 29, 2025 · CD8+ T cells serve as the immune system’s targeted killers, specializing in identifying and eliminating infected or cancerous cells. These cells are often referred to as “cytotoxic T lymphocytes” …

CD8+ (cytotoxic) T cells, like CD4+ Helper T cells, are generated in the thymus and express the T-cell receptor. However, rather than the CD4 molecule, cytotoxic T cells express a dimeric co-receptor, …

CD8 is a transmembrane glycoprotein that functions as a co-receptor for TCR engagement with MHC-I ligands. The CD8 co-receptor can be expressed as a heterodimer of CD8α and CD8β chains, …

Learn about cytotoxic T cells, also referred to as CD8+ T cells, including cell activation, differentiation, and function in adaptive immune response.

The biomarker CD3+/CD4-/CD8- identifies a unique subset of T lymphocytes that express the CD3 surface protein but lack both CD4 and CD8 co-receptors. These cells are often referred to as double …

While CD8 is widely recognized as a co-stimulatory molecule for conventional CD8 + αβ T cells, recent reports highlight its multifaceted role in both adaptive and innate immune responses. In this review, …