His wife, Usha Chilikuri Vance, garnered significant attention. She is the first Indian-American and Hindu American second lady. Media highlighted her Indian roots, tracing back to Andhra Pradesh. JD Vance acknowledged Usha's popularity in India.

Vice President JD Vance was less than two minutes into a speech in Jaipur, India this week, when he had a question for one of his most trusted advisers. He had just visited the Akshardham Temple, he said,

JD Vance joked of wife Usha during a speech, “She’s a bit of a celebrity, it turns out, in India. I think more so than her husband.”