When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found their footing with a ...

Breaking down all of the good and some of the bad from the 49ers’ much-needed blowout win over the Bears in Week 14.

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

San Francisco 49ers safety Talanoa Hufanga, defensive back Deommodore Lenoir and defensive lineman Jordan Elliott are set to ...

SportsLine's model simulated Chicago Bears vs. San Francisco 49ers 10,000 times and made its Week 14 NFL picks, predictions ...

It's the final week of byes and also the swan song for the regular season in some fantasy leagues, making for an intriguing ...

The San Francisco 49ers are facing another setback as defensive lineman Nick Bosa is officially out for Sunday's game.

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, playing 88% of the offensive snaps. In contrast, Jordan Mason has seen just 8% ...

With Christian McCaffrey on the shelf, the 49ers will turn to RB Isaac Guerendo, and he will deliver in Week 14 against the Bears!