Brock Purdy was listed as limited for Wednesday's practice by San Francisco 49ers head coach Kyle Shanahan, suggesting some reason for optimism ahead of their Week 13 matchup with the Buffalo Bills. But any positive feeling was soon overshadowed by what Purdy actually did in practice,

San Francisco 49ers are preparing to go head-to-head with a 9-2 Buffalo Bills team on Sunday night. San Francisco is hoping to have a number of stars return from injury for the game, but there is plenty of uncertainty at the moment.

San Francisco 49ers defensive end Nick Bosa (hip/oblique) was pulled from his team's Week 11 loss to the Seattle Seahawks due to an injury he suffered during the game. His absence was immediately felt, as the opposing team immediately marched down the field with little resistance.