Fantasy managers may need to proceed with caution before placing San Francisco's offensive players in their lineup this week.

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

How important has this defense been for the offense, and is it a sustainable formula for winning games this season?

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...

San Francisco 49ers quarterback Brock Purdy may be on track to return for the team’s Week 13 game against the Buffalo Bills.

San Francisco 49ers quarterback Brandon Allen could get a second consecutive start filling in for starter Brock Purdy (shoulder) when the 49ers play at the Buffalo Bills on Sunday night. Head coach ...

The arrow is pointing upward for Brock Purdy. On Friday, the 49ers delivered encouraging news on Purdy's status vs Buffalo in ...

Los Angeles Chargers (7-4) at Atlanta Falcons (6-5), 1 p.m. ET, FOX Atlanta holds a one-game lead over the Tampa Bay Buccaneers in the NFC South but lost the last ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night ...

But even when most or all of those Niners took the field this year, closing out games has been a glaring weakness for a team expected to compete for the NFC. A loss to Seattle in Week 11 marked the ...

Following their high-profile victory over the AFC-leading Chiefs, the Bills went off the NFL radar for their much-needed Week ...

San Francisco 49ers QB Brock Purdy shared his journey through injury recovery and looked ahead to the team's Week 13 matchup ...