For decades, statins have been the quiet workhorses of cardiology, cutting heart attack and stroke risk for millions while ...

Scientists organize millions of proteins by shape, as predicted by AI, revealing 700,000 new families and some shapes unique ...

This study revealed two independent retrograde pathways: a sorting nexin–mediated pathway (orange) and a core retromer–mediated pathway (blue). In yeast, sorting nexins and the core retromer form a ...

Proteins sustain life as we know it, serving many important structural and functional roles throughout the body. But these large molecules have cast a long shadow over a smaller subclass of proteins ...

Department of Biochemistry, Cell and Systems Biology, University of Liverpool, Liverpool, United Kingdom Bridge-like lipid transporters (BLTPs) have recently been revealed as key regulators of ...

The Golgi apparatus modifies, sorts and packages proteins to be sent to their final destinations, whether that's within or outside of the cell. It's a core function, but little studied in the setting ...

After viruses infected our evolutionary ancestors, bits of viral DNA lodged themselves into their genomes — and we still carry around genetic remnants of those viruses now. Known as endogenous ...

Mitochondria import hundreds of different precursor proteins from the cytosol. More than 50% of mitochondrial proteins do not use the classical import pathway that is guided by amino‐terminal ...

This cover highlights the article Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel by Bianca Introini, Wenqiang Cui, Xiaofeng Chu, Horst Vogel, Shuguang Yuan, Mikhail ...