Another piece of the dementia puzzle may finally have been found. In A Nutshell Scientists discovered ultrathin tubes (hundreds of nanometers wide) connecting brain cells that transport proteins and ...

Graphical Abstract: We developed a mechanistic model to simulate purification of a viral-protein complex by cation-exchange chromatography on the “wrong side” of the molecule’s isoelectric point (in a ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

Introduction Sarcopenia, osteoporosis and osteosarcopenia are conditions prevalent in ageing that impair muscle strength and bone density, increasing the risks of fractures, falls, disability and ...

A new study done by scientists in Switzerland and Sweden investigated the use of automated systems to develop multispecific antibodies. Multispecific antibodies (msAbs) are man-made drug modalities ...

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA. Defects in IVD function lead to toxic accumulation of metabolites such as isovaleric ...

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA. Defects in IVD function lead to toxic accumulation of metabolites such as isovaleric ...

Ion-exchange chromatography (IEC) is a common method for oligonucleotide purification (1, 2). Separation by IEC often uses strong–anion-exchange (AEX) resins at moderate to strongly basic pH values. A ...

Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32306, United States Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, ...

Introduction The escalating resistance of microorganisms to antimicrobials poses a significant public health threat. Strategies that use biomarkers to guide antimicrobial therapy—most notably ...