Just after midnight, Alaska Sen. Lisa Murkowski was pacing in a Senate hallway, alone and looking concerned. It had suddenly become clear to all her Republican colleagues that her vote would be their best chance of passing President Donald Trump’s sweeping bill of tax and spending cuts.

Provisions that would have shielded the state from some health care and food stamp cuts appear to be on the path to failure.

The Senate slogged through a tense overnight session that has now dragged into Tuesday morning, with Republican leaders searching for ways to secure support for President Donald Trump’s big bill of tax breaks and spending cuts while fending off proposed amendments,