When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found their footing with a ...

San Francisco 49ers head coach Kyle Shanahan provided injury updates following Sunday's 38-13 victory over the Chicago Bears. Rookie running back Isaac Guerendo, starting in place of the injured ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

San Francisco 49ers safety Talanoa Hufanga, defensive back Deommodore Lenoir and defensive lineman Jordan Elliott are set to ...

SportsLine's model simulated Chicago Bears vs. San Francisco 49ers 10,000 times and made its Week 14 NFL picks, predictions ...

It's the final week of byes and also the swan song for the regular season in some fantasy leagues, making for an intriguing ...

The San Francisco 49ers are facing another setback as defensive lineman Nick Bosa is officially out for Sunday's game.

The San Francisco 49ers are reportedly expected to lean on rookie running back Isaac Guerendo for the remainder of the 2024 ...

With Christian McCaffrey on the shelf, the 49ers will turn to RB Isaac Guerendo, and he will deliver in Week 14 against the Bears!

Both of these teams are nowhere near where they'd like to be this season, but with one finding a rejuvenated energy to themselves with a coaching change, here are three reasons for optimism for the ...