With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

The San Francisco 49ers just kept their season alive with a 38-13 statement win over the Chicago Bears. Here are the 49ers' ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

The Chicago Bears already have endured a brutal season. On Sunday, 10 days after team leaders fired coach Matt Eberflus, the ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

San Francisco 49ers running back Christian McCaffrey has spoken out after being placed on injured reserve with yet another ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Christian McCaffrey, at the premature end of a season that started late, too, waxed philosophical in a social media post on ...