This week’s 49ers mailbag is stocked with questions (and answers) regarding their offensive shortcomings, fourth-quarter ...

It isn’t news that running back and reigning Offensive Player of the Year Christian McCaffrey is a key cog in the 49ers’ ...

Dallas Cowboys tight end Jake Ferguson is well aware of the challenges the San Francisco 49ers defense presents the offense.

The Kansas City Chiefs are the only undefeated team remaining after seven weeks. The last time the final undefeated team won the Super Bowl was the 2006 Indianapolis Colts.

Coach Mike Tomlin’s bold move to start Russell Wilson over Justin Fields paid off for the Steelers in Sunday night’s win over ...

Coach Kyle Shanahan said tests Monday confirmed the initial diagnosis Aiyuk tore his ACL and would need major reconstructive ...

Jauan Jennings, wide receiver for the San Francisco 49ers, suffered a significant injury during a game against the Seattle ...

The San Francisco 49ers’ worst suspicions were confirmed Monday when it was learned Brandon Aiyuk was lost for the season ...

San Franciscco 49ers head coach Kyle Shanahan revealed that star receiver Deebo Samuel Sr. is currently hospitalized with pneumonia and fluid in his lungs after trying to play against the Kansas City ...

Chiefs, provides injury updates “San Francisco 49ers head coach Kyle Shanahan spoke with reporters during a conference call ...

Mahomes has more interceptions (eight) than touchdowns (six) this season and a career-low 82.5 passer rating. But a stingy ...

If the 49ers are serious about winning a Super Bowl this season, they might need to trade for a wide receiver. That's because Brandon Aiyuk is out for the seaso ...