See what Kyle Shanahan, Brock Purdy, Sean McDermott and Josh Allen had to say following the Week 13 primetime contest.

The 49ers just lost their second game in a row by at least 25 points for the first time since Jim Tomsula was the head coach.

San Francisco has dropped three straight, including meek losses to the Packers and Bills by a combined 53 points, to drop to ...

Rather than viewing this team as one of the class organizations of the NFC, we now need to ponder whether injuries, age, and ...

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on ...

The Los Angeles Rams' bitter rival suffered yet another devastating injury during their Week 13 road loss against the Buffalo ...

The San Francisco 49ers suffered another disappointing loss on Sunday night as they took on the Buffalo Bills on the road in ...

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle Shanahan said Sunday night.

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.