Skenes fell to 0-4 in five career starts against the Cardinals after a 2-1 loss Tuesday night. It's the most starts by a Pirates pitcher to begin a career against St. Louis without a win since JT Brubaker went 0-6 in eight starts in 2021 and 2022.

Two RBIs from Alec Burleson, seven innings from starter Matthew Liberatore and a save in his first opportunity by Gordon Graceffo helped the Cardinals beat the Pirates 2-1 on Tuesday.

Cardinals first baseman Alec Burleson was 1-3 against Skenes Tuesday night, including his first extra-base hit. The 26-year-old is a career six-for-15 (.400) with four RBI when facing Skenes, with the most hits off him than any other major leaguer.