The effect of a targeted agent on a cancer patient's clinical outcome putatively is mediated through the agent's effect on one or more early biological events. This is motivated by pre-clinical ...

Patients were stratified to cohort A (unspecified tumors) or cohort B (rare genomic alterations). The TARGET-CRM design permits cohort B patients to immediately enroll at one dose level below the ...

Suppose we have a group of Bayesian agents, and suppose that they would like for their group as a whole to be a Bayesian agent as well. Moreover, suppose that those agents want the probabilities and ...