The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC), which ...

on topics around the role of androgen receptors, including but not limited to: Hormone signaling and reproductive functions Pathogenesis of Polycystic Ovary Syndrome Pathogenesis of Testicular ...

The understanding of the biology of CRPC and the evidence that CRPC still remains driven by androgen receptor signaling led to the discovery of new therapeutic targets. In the last few years ...

Dr. Bernard-Tessier notes that androgen receptor signaling inhibitors are the mainstay of prostate cancer treatment, however despite considerable benefit of 2 nd generation androgen receptor signaling ...

The key to this resistance may lie in expression of the androgen receptor itself. Most patients with metastatic prostate cancer receive drugs that block production of androgen, which promotes ...

and little is known about the precise downstream effects of androgen-receptor signalling in HRPC and the ability to exploit the effects therapeutically. The Akt-PI3K (phosphatidylinositol 3L'-kinase) ...

Dr. Ryuma Tanaka presented the results of a retrospective study of patients with metastatic hormone sensitive prostate cancer (mHSPC) and the impact of delayed administration of androgen receptor ...

"Unfortunately, most patients with advanced, metastatic disease who are treated with drugs to inhibit androgen signaling will ... the androgen receptor is encouraged to "go solo" in the cell.

Astrazeneca AB has divulged proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase cereblon unit coupled to an androgen receptor (AR) targeting moiety via a linker acting as AR ...