San Francisco 49ers offensive tackle Trent Williams was seen in the locker room on Wednesday using a scooter as he recovers ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4.

SANTA CLARA — Quarterback Brock Purdy is scheduled for limited practice on Wednesday as the 49ers return to work after a ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The 49ers have revealed their latest injury report before their Sunday Night Football tilt against the Buffalo Bills.

The 49ers are welcoming Brock Purdy back to practice today after shoulder soreness kept him out of Sunday’s loss at Green Bay ...

As injuries stack up, the San Francisco 49ers went and found some offensive line help to sign to their practice squad.

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Amid a wicked Super Bowl hangover and heading towards what is likely a losing season, it’s natural that head coach Kyle ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

SANTA CLARA — While Brock Purdy resumed practicing through a shoulder issue and Dre Greenlaw made a much-anticipated debut ...