It was during a chat with CBS Mornings that Demi Moore opened up about the raw vulnerability required to bring some of the harder emotional scenes to life. As explained in a clip

It's rare for a movie like "The Substance" to break into the Oscars race. Written and directed by French filmmaker Coralie Fargeat, the film is an intense, satirical and violent body horror thriller about insecurity and the pressures of the unrealistic beauty standards that society forces onto women both when they are young and when they are older.

Demi Moore, who is nominated for Best Actress at the 2025 Oscars, and Margaret Qualley, who plays a younger version of Moore's character in Coralie Fargeat's horror film 'The Substance,' each put their bodies on the line for the demanding shoot.