George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

The first-place Buffalo Bills are on a six-game winning streak and getting healthier. The last-place San Francisco 49ers have ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

Buffalo Bills look to extend its six-game win streak as Josh Allen faces an unfamiliar foe in the San Francisco 49ers at ...

Leonard Floyd is excited to face superstar quarterback Josh Allen and his old Buffalo Bills on Sunday. Floyd, a nine-year ...

The Bills will take on the San Francisco 49ers on Sunday night at Highmark Stadium in Orchard Park. Lake-effect snow bands ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

Coming out of their bye week, the Bills take a six-game winning streak into their Week 13 matchup with the 49ers.

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...