NFL Week 5 has arrived and we asked USA TODAY Sports' staff for their best NFL bets today for the entire slate. Here are their picks and predictions.

NFL RedZone — an around-the-horn live highlight show demonstrating all the action on NFL Sunday — is back for Week 5 of the 2025 season.

In Week 5, nine underdogs covered in 14 games and every one of our NFL experts finished with a record above .500.

Week 5 in the NFL featured several aspiring contenders showing cracks in composure, with the Cardinals and Bills among those losing their cool.

How teams are trending after Sunday of Week 5 resulted in stunning upsets and improbable comebacks — often in the same game.

Who dethroned Josh Allen for the top spot in Nick Shook's QB Index rankings? Check out the updated pecking order, 1-32, heading into Week 6 of the 2025 NFL season.

The Rams have a light injury report. Tight end Tyler Higbee (hip) and tackle Rob Haverstein (ankle) did not practice. Tight end Colby Parkinson (concussion) is limited.

As good as Darnold was, Tampa Bay quarterback Baker Mayfield was even better, going 29-for-33 for 379 yards and two touchdowns. His 11-yard touchdown pass to Sterling Shephard with 1:08 to play tied the score at 35 and set the stage for the win.

Jason Lisk at PoolGenius ranked the worst survival pool bad beats, and he had the Cardinals' 22-21 loss on Sunday at No. 1. It's hard to argue. If you're still alive for Week 6 because you didn't pick the Cardinals (or Rams, or Bills), then you're already playing with house money.

Head coach Kyle Shanahan expects his team to continue playing shorthanded when they face the Buccaneers on Sunday; he said the 49ers are "not counting on" WR Ricky Pearsall returning in Week 6 and that TE George Kittle is eyeing a Week 7 return.