Researchers have discovered a non-opioid compound that, in mice, effectively reduced the pain hypersensitivity associated with chronic and often debilitating nerve pain caused by diabetes or ...

Unfortunately, nonopioid analgesics are often disappointingly ineffective against neuropathic pain. Topically applied medications (e.g., capsaicin, lidocaine) may be useful in some cases, especially ...

Among the most difficult types of pain to alleviate is neuropathic pain, pain that is usually caused by damage to nerves in various body tissues, including skin, muscle and joints. It can cause ...

A new approach to treating neuropathic pain is making a key step forward thanks to researchers at The University of Texas at Austin. Among the most difficult types of pain to alleviate is neuropathic ...

Though increasingly prescribed in the U.S., a 2025 study linked gabapentin prescriptions for chronic low back pain with ...

A new approach to treating neuropathic pain is making a key step forward. Neuropathic pain is among the most difficult types of pain to alleviate and current treatments are often ineffective.

In a recent study published in PNAS, researchers investigated the selective activity of sigmoid 2 receptor (σ2R) or transmembrane protein 97 (TMEM97) ligands on murine neuropathic pain models, their ...

A major breakthrough in our understanding of pain has been revealed in a collaborative study led by a Leeds scientist, opening the door to new ways of tackling long term pain without harmful and ...

Dec 13 (Reuters) - Vertex Pharmaceuticals' (VRTX.O), opens new tab non-opioid painkiller significantly decreased pain in patients with diabetes suffering from chronic nerve pain in a mid-stage trial, ...

At least eight states now require insurers to cover alternatives without higher co-pays or extra hurdles.<br/> ...

The opioid crisis remains a significant public health challenge in the United States. In 2022, over 2.5 million American adults had an opioid use disorder, and opioids accounted for nearly 76% of ...

A new approach to treating neuropathic pain is making a key step forward thanks to researchers at The University of Texas at Austin. Martha Morales/The University of Texas at Austin Among the most ...