Subtle changes in neurotransmission that occur during Alzheimer’s disease have been tough to track in living people. A new positron emission tomography tracer may change that. In the January 12 ...

Muscarinic acetylcholine receptors (mAChRs) are central to the modulation of neurotransmission in the human brain and are emerging as promising targets in the management of neuropsychiatric disorders.

Researchers have identified a mechanism by which acetylcholine, a neurotransmitter best known for its role in muscle control ...

Introduction Studies on human patellar and Achilles tendons have shown that tendon cells not only have the capacity to produce acetylcholine (ACh) but also express muscarinic ACh receptors (mAChRs), ...

The production of toxic Aβ peptides from amyloid precursor protein (APP) proceeds via the sequential cleavage of the extracellular domain by β-secretase, followed by an intramembrane cut by ...

2 Department of Psychiatry, University of Toronto, Faculty of Medicine, 33 Russell Street, T-109 Toronto, ON M5S 2S1, Canada 3 Multimodal Imaging Group, Centre for Addiction & Mental Health, Toronto, ...

Researchers have found that blocking certain acetylcholine receptors in the lateral habenula (LHb), an area of the brain that balances reward and aversion, made it harder to resist seeking cocaine in ...

Cocaine, opioids, and other drugs of abuse disrupt the brain's reward system, often shifting users' priorities to obtaining more drug above all else. For people battling addiction, this persistent ...

The selective muscarinic agonist is now in mid-stage development for movement disorders like Parkinson’s disease and dystonia ...

More than 60% of complement inhibitor–naive patients with acetylcholine receptor–positive generalized myasthenia gravis (MG) in diverse clinical populations had a clinically meaningful reduction in MG ...