The Supreme Court will hear oral arguments Wednesday over Tennessee’s ban on gender-affirming care for minors, a landmark case that will have implications nationwide as Republicans have increasingly targeted transgender rights and enacted bans on healthcare for minors across the country.

Supreme Court justices on Wednesday used the preferred honorific of the first openly transgender-identifying person to argue before the high court during oral arguments in a landmark case on the ability of states to regulate hormone-based therapies for minors with gender dysphoria.