In the memoir, Kelsey – whose life has been marred by tragedy including the 1968 murder of his father in Saint Thomas and the death of two teenage half-brothers in 1980 – shared how detectives came to the Grammer family home in Pompano Beach, FL to tell the family that they had discovered a Jane Doe they thought might be Karen.

Kelsey Grammer says that he drank, used drugs, and engaged in 'fairly exotic sexual behavior' to cope with the horrific murder of his sister Karen in 1975: 'A lot of fun and then the fun ran out.'

Kelsey Grammer is opening up about the 1975 murder of his sister, Karen Grammer, in his new book "Karen: A Brother Remembers."