The star said that she fell while running across a field during a scene for the dark comedy and now realizes it was an early sign of her autoimmune condition. “I remember falling that day,” recalled Applegate. “Hi, first sign of MS!” Feldman also remembered the incident.

And since revealing her diagnosis, Applegate has been open in speaking out about some of the 'weird' symptoms she experienced - not realizing at the time they were a sign of MS. In an ABC News interview, Applegate told Robin Roberts that there was one particular symptom which began 'in the early part of 2021'.

Christina Applegate has opened up about how she ignored the early symptoms of Multiple Sclerosis while shooting early episodes of comedy-drama ‘Dead To Me’

Actress Christina Applegate has been open about her struggles with multiple sclerosis, which she was diagnosed with back in 2021 — but evidently, her symptoms had already been present two years prior.

Christina Applegate has revealed she noticed her first MS symptom while filming the Dead To Me pilot episode in her latest Messy podcast episode.

Christina Applegate dismissed early multiple sclerosis (MS) symptoms while filming Netflix's Dead To Me. The actor starred as Jen Harding in the Emmy-nominated dark comedy, which premiered in 2019 and ran for three seasons.

Applegate's symptoms were initially dismissed. Applegate confessed to brushing off her symptoms at first and postponing medical assistance. Recalling the 2019 incident, she said,

Christina Applegate was diagnosed with Multiple Sclerosis in 2021 - but the actress has revealed that she first noticed mysterious symptoms more than two years earlier, while shooting the pilot episode of Dead To Me.